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KMID : 0665220190320020138
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Korean Journal of Food and Nutrition
2019 Volume.32 No. 2 p.138 ~ p.147
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Antioxidative Activities and Inhibitory Effects on Lipid Accumulation of Extracts fromDifferent Parts of Morus alba and Cudrania tricuspidata
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Kim Gun-Hee
Kim Eun-Hyang
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Abstract
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In this study, we examined antioxidative effects and the anti-adipogenesis effect of different parts of Cudrania tricuspidata (C), and Morus alba (M). Total polyphenol contents were highest in M-root (34.56±0.045 mg GAE/g), and there was no significant difference, between C-root and M-leaf. Total flavonoid contents of C-root were highest (23.07±0.004 mg QE/g). To examine antioxidant activities of C and M extracts, DPPH and ABTS radical scavenging activity, and FRAP assay, was used. Results show that antioxidant activities of C and M extracts increased, in a dose-dependent manner. Adipocytes are generated by preadipocyte differentiation, during adipogenesis. Matured adipocytes accumulate in abnormal and cause obesity. We investigated effects of leaf and root extracts of C and M, on lipid accumulation, in 3T3-L1 adipocytes. Changes in cell morphology, and degrees of lipid accumulation in adipocytes, were evaluated by Oil Red O staining. Root extracts of C and M, reduced lipid content in a dose-dependent manner. Therefore, root extracts of C and M, may be good candidates for managing obesity.
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KEYWORD
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Cudrania tricuspidata, Morus alba, antioxidative activity, 3T3-L1, adipogenesis
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